Aceclofenac 100mg + Paracetamol 325mg + Chlorzoxazone 250mg

Gogesic-MR tablet is a triple-combination medication widely prescribed for the management of musculoskeletal pain, inflammation, and muscle spasms. It provides comprehensive relief by combining an anti-inflammatory agent, an analgesic–antipyretic, and a centrally acting muscle relaxant.

Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins responsible for pain, inflammation, and swelling. It provides effective relief in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other inflammatory disorders.

Paracetamol (Acetaminophen) acts as an analgesic and antipyretic. It enhances the pain-relieving effect of aceclofenac and helps reduce fever by acting on the hypothalamic heat-regulating center. It has minimal gastrointestinal irritation compared to NSAIDs, making the combination safer for prolonged use under medical supervision.

Chlorzoxazone is a centrally acting skeletal muscle relaxant that helps relieve painful muscle spasms without significantly impairing muscle function. It acts on the spinal cord and subcortical areas of the brain to reduce skeletal muscle hyperactivity, improving mobility and comfort.

Therapeutic uses: This combination is commonly used to treat back pain, cervical spondylosis, lumbago, sprains, strains, myalgia, arthritis, and other musculoskeletal conditions associated with pain and muscle stiffness.

Dosage and administration: The usual adult dose is one tablet two to three times daily after meals, as directed by the physician.

Side effects: Possible adverse effects include nausea, abdominal discomfort, dizziness, drowsiness, heartburn, and, rarely, allergic reactions or liver function abnormalities.

Precautions: It should be used with caution in patients with liver or kidney impairment, gastric ulcers, or alcohol dependence. Prolonged or excessive use should be avoided.

Conclusion: The Gogesic-MR combination offers synergistic benefits in pain management, providing effective relief from musculoskeletal pain, inflammation, and spasm with a good safety profile when used as directed by a healthcare professional.